GnRH-R targeted lytic peptide sensitizes BRCA wild-type ovarian cancer to PARP inhibition

EP-100 is a synthetic lytic peptide that specifically targets the gonadotropin-releasing hormone receptor on cancer cells. To extend the utility of EP-100, we aimed to identify effective combination therapies with EP-100 for ovarian cancer and explore potential mechanisms of this combination. A seri...

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Udgivet i:Mol Cancer Ther
Main Authors: Ma, Shaolin, Pradeep, Sunila, Villar-Prados, Alejandro, Wen, Yunfei, Bayraktar, Emine, Mangala, Lingegowda S., Kim, Mark Seungwook, Wu, Sherry Y., Hu, Wei, Rodriguez-Aguayo, Cristian, Leuschner, Carola, Liang, Xiaoyan, Ram, Prahlad T., Schlacher, Katharina, Coleman, Robert L., Sood, Anil K.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497555/
https://ncbi.nlm.nih.gov/pubmed/30926640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0770
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