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Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2‐M and induces ROS‐independent apoptosis in A549 cells, targeting nuclear DNA
OBJECTIVES: The K‐ras gene mutation commonly found in lung adenocarcinomas contributes to their non‐invasive expansion. Our main objective here was to develop a chemopreventive agent against K‐ras‐mutated lung adenocarcinoma cell line like‐A549. MATERIALS AND METHODS: We isolated flavonol from ethan...
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| Veröffentlicht in: | Cell Prolif |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6496600/ https://ncbi.nlm.nih.gov/pubmed/24267912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12079 |
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