Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2‐M and induces ROS‐independent apoptosis in A549 cells, targeting nuclear DNA

OBJECTIVES: The K‐ras gene mutation commonly found in lung adenocarcinomas contributes to their non‐invasive expansion. Our main objective here was to develop a chemopreventive agent against K‐ras‐mutated lung adenocarcinoma cell line like‐A549. MATERIALS AND METHODS: We isolated flavonol from ethan...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cell Prolif
Huvudupphovsmän: Mukherjee, A., Sikdar, S., Bishayee, K., Boujedaini, N., Khuda‐Bukhsh, A. R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2013
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496600/
https://ncbi.nlm.nih.gov/pubmed/24267912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12079
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk