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X‐irradiation effects on thymidine kinase (TK): II. The significance of deoxythymidine triphosphate for inhibition of TK1 activity

Abstract. The purpose of this study was to investigate the mechanism behind the high sensitivity of thymidine kinase 1 (TK1) to X‐irradiation. The deoxythymidine triphosphate (dTTP) pool was studied in mouse ascites tumour cells 1–24 h after X‐irradiation with 5 Gy. Irradiation changed the Michaelis...

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Pubblicato in:Cell Prolif
Autori principali: He, Q., Skog, S., Welander, I., Tribukait, B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Ltd 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496500/
https://ncbi.nlm.nih.gov/pubmed/11952643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2184.2002.00227.x
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