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Influence on antiproliferative activity of structural modification and conjugation of gonadotropin‐releasing hormone (GnRH) analogues

The effect of various GnRH analogues, and their conjugates on proliferation, clonogenicity and cell cycle phase distribution of MCF‐7 and Ishikawa human cancer cell lines was studied. GnRH‐III, a sea lamprey GnRH analogue reduced cell proliferation by 35% and clonogenicity by 55%. Structural modific...

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發表在:Cell Prolif
Main Authors: Kálnay, A., Pályi, I., Vincze, B., Mihalik, R., Mezõ, I., Pató, J., Seprõdi, J., Lovas, S., Murphy, R.F.
格式: Artigo
語言:Inglês
出版: Blackwell Science Ltd 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496190/
https://ncbi.nlm.nih.gov/pubmed/11063130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2184.2000.00180.x
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