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Influence on antiproliferative activity of structural modification and conjugation of gonadotropin‐releasing hormone (GnRH) analogues

The effect of various GnRH analogues, and their conjugates on proliferation, clonogenicity and cell cycle phase distribution of MCF‐7 and Ishikawa human cancer cell lines was studied. GnRH‐III, a sea lamprey GnRH analogue reduced cell proliferation by 35% and clonogenicity by 55%. Structural modific...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Kálnay, A., Pályi, I., Vincze, B., Mihalik, R., Mezõ, I., Pató, J., Seprõdi, J., Lovas, S., Murphy, R.F.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Ltd 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496190/
https://ncbi.nlm.nih.gov/pubmed/11063130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2184.2000.00180.x
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