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In silico study of the impact of cancer stem cell dynamics and radiobiological hypoxia on tumour response to hyperfractionated radiotherapy

OBJECTIVES: Advanced head and neck carcinomas (HNCs) are aggressive tumours, mainly due to hypoxia and a cancer stem cell (CSC) subpopulation. The aim of this study was to simulate tumour growth and behaviour during radiotherapy of three HNC groups (governed by different growth kinetics, hypoxia lev...

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Bibliografiske detaljer
Udgivet i:Cell Prolif
Main Authors: Marcu, L. G., Marcu, D., Filip, S. M.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495993/
https://ncbi.nlm.nih.gov/pubmed/27079860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12251
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