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Glycopeptide antibiotic biosynthesis: Enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine

Four proteins, DpgA–D, required for the biosynthesis by actinomycetes of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg), that is a crosslinking site in the maturation of vancomycin and teicoplanin antibiotic scaffolds, were expressed in Escherichia coli, purified in sol...

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Detalhes bibliográficos
Main Authors: Chen, Huawei, Tseng, Claire C., Hubbard, Brian K., Walsh, Christopher T.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC64956/
https://ncbi.nlm.nih.gov/pubmed/11752437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221582098
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