Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury

Cerebral edema in ischemic stroke can lead to increased intracranial pressure, reduced cerebral blood flow and neuronal death. Unfortunately, current therapies for cerebral edema are either ineffective or highly invasive. During the development of cytotoxic and subsequent ionic cerebral edema water...

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Vydáno v:Neuroscience
Hlavní autoři: Farr, George W, Hall, Christopher H, Farr, Susan M, Wade, Ramon, Detzel, Joshua M, Adams, Amielia G, Buch, Jasen M, Beahm, Derek L, Flask, Christopher A, Xu, Kui, LaManna, Joseph C, McGuirk, Paul R, Boron, Walter F, Pelletier, Marc F
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495193/
https://ncbi.nlm.nih.gov/pubmed/30738082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2019.01.034
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