Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury

Cerebral edema in ischemic stroke can lead to increased intracranial pressure, reduced cerebral blood flow and neuronal death. Unfortunately, current therapies for cerebral edema are either ineffective or highly invasive. During the development of cytotoxic and subsequent ionic cerebral edema water...

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Bibliografske podrobnosti
izdano v:Neuroscience
Main Authors: Farr, George W, Hall, Christopher H, Farr, Susan M, Wade, Ramon, Detzel, Joshua M, Adams, Amielia G, Buch, Jasen M, Beahm, Derek L, Flask, Christopher A, Xu, Kui, LaManna, Joseph C, McGuirk, Paul R, Boron, Walter F, Pelletier, Marc F
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495193/
https://ncbi.nlm.nih.gov/pubmed/30738082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2019.01.034
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