Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury

Cerebral edema in ischemic stroke can lead to increased intracranial pressure, reduced cerebral blood flow and neuronal death. Unfortunately, current therapies for cerebral edema are either ineffective or highly invasive. During the development of cytotoxic and subsequent ionic cerebral edema water...

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Udgivet i:Neuroscience
Main Authors: Farr, George W, Hall, Christopher H, Farr, Susan M, Wade, Ramon, Detzel, Joshua M, Adams, Amielia G, Buch, Jasen M, Beahm, Derek L, Flask, Christopher A, Xu, Kui, LaManna, Joseph C, McGuirk, Paul R, Boron, Walter F, Pelletier, Marc F
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495193/
https://ncbi.nlm.nih.gov/pubmed/30738082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2019.01.034
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