Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice

Transmitter release at auditory inner hair cell (IHC) ribbon synapses involves exocytosis of glutamatergic vesicles during voltage activation of L-type Ca(v)1.3 calcium channels. At these synapses, the fast and indefatigable release of synaptic vesicles by IHCs is controlled by otoferlin, a six-C2-d...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Tertrais, Margot, Bouleau, Yohan, Emptoz, Alice, Belleudy, Séverin, Sutton, R. Bryan, Petit, Christine, Safieddine, Saaid, Dulon, Didier
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495124/
https://ncbi.nlm.nih.gov/pubmed/30833506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1550-18.2018
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