Characterizing ABC-Transporter Substrate-Likeness Using a Clean-Slate Genetic Background

Mutations in ATP Binding Cassette (ABC)-transporter genes can have major effects on the bioavailability and toxicity of the drugs that are ABC-transporter substrates. Consequently, methods to predict if a drug is an ABC-transporter substrate are useful for drug development. Such methods traditionall...

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Publicado en:Front Pharmacol
Autores principales: Sokolov, Artem, Ashenden, Stephanie, Sahin, Nil, Lewis, Richard, Erdem, Nurdan, Ozaltan, Elif, Bender, Andreas, Roth, Frederick P., Cokol, Murat
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494965/
https://ncbi.nlm.nih.gov/pubmed/31105571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00448
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