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Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion
Key features for progression to pancreatic β-cell failure and disease are loss of glucose responsiveness and an increased ratio of secreted proinsulin to insulin. Proinsulin and insulin are stored in secretory granules (SGs) and the fine-tuning of hormone output requires signal-mediated recruitment...
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| Pubblicato in: | J Mol Endocrinol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6494717/ https://ncbi.nlm.nih.gov/pubmed/30407917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JME-18-0048 |
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