CARD9(+) Microglia Promote Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment

The C-type lectin receptor–Syk adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CNS), as human CARD9-deficiency causes fungal-specific CNS-targeted infection susceptibility. CARD9 promotes neutrophil recruitment to the fungal-infected CNS, which mediates fu...

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Publicat a:Nat Immunol
Autors principals: Drummond, Rebecca A., Swamydas, Muthulekha, Oikonomou, Vasileios, Zhai, Bing, Dambuza, Ivy M., Schaefer, Brian C., Bohrer, Andrea C., Mayer-Barber, Katrin D., Lira, Sergio A., Iwakura, Yoichiro, Filler, Scott G., Brown, Gordon D., Hube, Bernhard, Naglik, Julian R., Hohl, Tobias M., Lionakis, Michail S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494474/
https://ncbi.nlm.nih.gov/pubmed/30996332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0377-2
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