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The FKBP12 subunit modifies the long-range allosterism of the ryanodine receptor
Ryanodine receptors (RyRs) are large conductance intracellular channels controlling intracellular calcium homeostasis in myocytes, neurons, and other cell types. Loss of RyR’s constitutive cytoplasmic partner FKBP results in channel sensitization, dominant subconductance states, and increased cytopl...
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| Udgivet i: | J Struct Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6494473/ https://ncbi.nlm.nih.gov/pubmed/30641143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2018.12.007 |
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