Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study

PURPOSE: Androgen receptor splice variant 7 (AR-V7) results in a truncated receptor, which leads to ligand-independent constitutive activation that is not inhibited by anti-androgen therapies, including abiraterone or enzalutamide. Given that previous reports suggested that circulating tumor cell (C...

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Pubblicato in:J Clin Oncol
Autori principali: Armstrong, Andrew J., Halabi, Susan, Luo, Jun, Nanus, David M., Giannakakou, Paraskevi, Szmulewitz, Russell Z., Danila, Daniel C., Healy, Patrick, Anand, Monika, Rothwell, Colin J., Rasmussen, Julia, Thornburg, Blair, Berry, William R., Wilder, Rhonda S., Lu, Changxue, Chen, Yan, Silberstein, John L., Kemeny, Gabor, Galletti, Giuseppe, Somarelli, Jason A., Gupta, Santosh, Gregory, Simon G., Scher, Howard I., Dittamore, Ryan, Tagawa, Scott T., Antonarakis, Emmanuel S., George, Daniel J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2019
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494355/
https://ncbi.nlm.nih.gov/pubmed/30865549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.18.01731
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