Structural basis for the activation of human procaspase-7

Caspases form a family of proteinases required for the initiation and execution phases of apoptosis. Distinct proapoptotic stimuli lead to activation of the initiator caspases-8 and -9, which in turn activate the common executioner caspases-3 and -7 by proteolytic cleavage. Whereas crystal structure...

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Bibliografiska uppgifter
Huvudupphovsmän: Riedl, Stefan J., Fuentes-Prior, Pablo, Renatus, Martin, Kairies, Norman, Krapp, Stephan, Huber, Robert, Salvesen, Guy S., Bode, Wolfram
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC64937/
https://ncbi.nlm.nih.gov/pubmed/11752425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221580098
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