Surgery Upregulates High Mobility Group Box‐1 and Disrupts the Blood–Brain Barrier causing Cognitive Dysfunction in Aged Rats

AIM: Postoperative cognitive dysfunction (POCD) is a growing and largely underestimated problem without defined etiology. Herein, we sought to determine the relationship between cognitive decline, blood–brain barrier (BBB) permeability, and inflammation, namely high mobility group box‐1 (HMGB1), aft...

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Pubblicato in:CNS Neurosci Ther
Autori principali: He, Hui‐Juan, Wang, Yi, Le, Yuan, Duan, Kai‐Ming, Yan, Xue‐Bin, Liao, Qin, Liao, Yan, Tong, Jian‐Bin, Terrando, Niccolò, Ouyang, Wen
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2012
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493557/
https://ncbi.nlm.nih.gov/pubmed/23078219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12018
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