Surgery Upregulates High Mobility Group Box‐1 and Disrupts the Blood–Brain Barrier causing Cognitive Dysfunction in Aged Rats

AIM: Postoperative cognitive dysfunction (POCD) is a growing and largely underestimated problem without defined etiology. Herein, we sought to determine the relationship between cognitive decline, blood–brain barrier (BBB) permeability, and inflammation, namely high mobility group box‐1 (HMGB1), aft...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: He, Hui‐Juan, Wang, Yi, Le, Yuan, Duan, Kai‐Ming, Yan, Xue‐Bin, Liao, Qin, Liao, Yan, Tong, Jian‐Bin, Terrando, Niccolò, Ouyang, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2012
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493557/
https://ncbi.nlm.nih.gov/pubmed/23078219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12018
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