Drug Binding Assays do not Reveal Specific Binding of Lacosamide to Collapsin Response Mediator Protein 2 (CRMP‐2)

Aims: Lacosamide (LCM; SPM 927, Vimpat®) is an antiepileptic drug (AED) used as adjunctive treatment for adults with partial‐onset seizures. LCM has a different mode of action from traditional sodium channel blocking AEDs in that it selectively enhances slow inactivation of sodium channels without a...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Wolff, Christian, Carrington, Bruce, Varrin‐Doyer, Michel, Vandendriessche, Anne, Van der Perren, Christy, Famelart, Michel, Gillard, Michel, Foerch, Patrik, Rogemond, Véronique, Honnorat, Jerôme, Lawson, Alastair, Miller, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493415/
https://ncbi.nlm.nih.gov/pubmed/22672303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-5949.2012.00313.x
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