T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy

Post-translational modifications are induced in stressed cells which cause them to be recognised by the system. One such modification is citrullination where the positive charged arginine is modified to a neutral citrulline. We demonstrate most healthy donors show an oligoclonal CD4 response in vitr...

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Détails bibliographiques
Publié dans:Oncoimmunology
Auteurs principaux: Brentville, Victoria A, Symonds, Peter, Cook, Katherine W, Daniels, Ian, Pitt, Tracy, Gijon, Mohamed, Vaghela, Poonam, Xue, Wei, Shah, Sabaria, Metheringham, Rachael L, Durrant, Lindy G
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2019
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492960/
https://ncbi.nlm.nih.gov/pubmed/31069134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1576490
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