Targeting the ICOS/ICOS‐L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

BACKGROUND: Allergic asthma is characterized by chronic inflammation and remodelling of the airways, associated with dysregulated type 2 immune responses and allergen‐specific IgE. T follicular helper cells (T(FH)) are crucial in T‐dependent B‐cell responses and have been implicated in allergic airw...

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Udgivet i:Allergy
Main Authors: Uwadiae, Faith I., Pyle, Chloe J., Walker, Simone A., Lloyd, Clare M., Harker, James A.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
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ORIGINAL ARTICLES
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492018/
https://ncbi.nlm.nih.gov/pubmed/30220084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.13602
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