Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21

Background: Natural Killer (NK) cell-based immunotherapy used to treat cancer requires the adoptive transfer of a large number of activated NK cells. Here, we report a new effective method to expand human NK cells ex vivo using K562 cells genetically engineered (GE) to express OX40 ligand (K562-OX40...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kweon, SoonHo, Phan, Minh-Trang Thi, Chun, Sejong, Yu, HongBi, Kim, Jinho, Kim, Seokho, Lee, Jaemin, Ali, Alaa Kassim, Lee, Seung-Hwan, Kim, Sang-Ki, Doh, Junsang, Cho, Duck
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491902/
https://ncbi.nlm.nih.gov/pubmed/31105701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00879
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