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Methylobacterium extorquens RSH Enzyme Synthesizes (p)ppGpp and pppApp in vitro and in vivo, and Leads to Discovery of pppApp Synthesis in Escherichia coli

In bacteria, the so-called stringent response is responsible for adaptation to changing environmental conditions. This response is mediated by guanosine derivatives [(p)ppGpp], synthesized by either large mono-functional RelA or bi-functional SpoT (synthesis and hydrolysis) enzymes in β- and γ-prote...

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Bibliografiske detaljer
Udgivet i:Front Microbiol
Main Authors: Sobala, Michał, Bruhn-Olszewska, Bożena, Cashel, Michael, Potrykus, Katarzyna
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491832/
https://ncbi.nlm.nih.gov/pubmed/31068922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00859
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