Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells

Due to a missense mutation in the Foxp3 gene, scurfy mice are deficient in functional regulatory T cells (Treg). The consequent loss of peripheral tolerance manifests itself by fatal autoimmune mediated multi-organ disease. Previous studies have outlined the systemic inflammatory disease and demonst...

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Foilsithe in:Front Immunol
Main Authors: Yilmaz, Osman K., Haeberle, Stefanie, Zhang, Meifeng, Fritzler, Marvin J., Enk, Alexander H., Hadaschik, Eva N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491778/
https://ncbi.nlm.nih.gov/pubmed/31068947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00881
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