Transgenic Expression of miR-133a in the Diabetic Akita Heart Prevents Cardiac Remodeling and Cardiomyopathy

Advanced diabetes mellitus (DM) may have both insulin resistance and deficiency (double DM) that accelerates diabetic cardiomyopathy (DMCM), a cardiac muscle disorder. Reduced cardiac miR-133a, a cardioprotective miRNA, is associated with DMCM. However, it is unclear whether increasing miR-133a leve...

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Publicado en:Front Cardiovasc Med
Autores principales: Kambis, Tyler N., Shahshahan, Hamid R., Kar, Sumit, Yadav, Santosh K., Mishra, Paras K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Cardiovascular Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491745/
https://ncbi.nlm.nih.gov/pubmed/31069235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2019.00045
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