Robust Generation of Person-Specific, Synchronously Active Neuronal Networks Using Purely Isogenic Human iPSC-3D Neural Aggregate Cultures

Reproducibly generating human induced pluripotent stem cell-based functional neuronal circuits, solely obtained from single individuals, poses particular challenges to achieve personalized and patient specific functional neuronal in vitro models. A hallmark of functional neuronal assemblies, synchro...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Izsak, Julia, Seth, Henrik, Andersson, Mats, Vizlin-Hodzic, Dzeneta, Theiss, Stephan, Hanse, Eric, Ågren, Hans, Funa, Keiko, Illes, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491690/
https://ncbi.nlm.nih.gov/pubmed/31068774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00351
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