TGF-β1 Suppresses Proliferation and Induces Differentiation in Human iPSC Neural in vitro Models

Persistent neural stem cell (NSC) proliferation is, among others, a hallmark of immaturity in human induced pluripotent stem cell (hiPSC)-based neural models. TGF-β1 is known to regulate NSCs in vivo during embryonic development in rodents. Here we examined the role of TGF-β1 as a potential candidat...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Izsak, Julia, Vizlin-Hodzic, Dzeneta, Iljin, Margarita, Strandberg, Joakim, Jadasz, Janusz, Olsson Bontell, Thomas, Theiss, Stephan, Hanse, Eric, Ågren, Hans, Funa, Keiko, Illes, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655796/
https://ncbi.nlm.nih.gov/pubmed/33195202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.571332
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