Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning

BACKGROUND: Genome-scale metabolic models (GEMs) offer insights into cancer metabolism and have been used to identify potential biomarkers and drug targets. Drug repositioning is a time- and cost-effective method of drug discovery that can be applied together with GEMs for effective cancer treatment...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Turanli, Beste, Zhang, Cheng, Kim, Woonghee, Benfeitas, Rui, Uhlen, Mathias, Arga, Kazim Yalcin, Mardinoglu, Adil
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491384/
https://ncbi.nlm.nih.gov/pubmed/30905848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.009
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