Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer

Triple-negative breast cancer (TNBC), which is largely synonymous with the basal-like molecular subtype, is the 5th leading cause of cancer deaths for women in the United States. The overall prognosis for TNBC patients remains poor given that few treatment options exist; including targeted therapies...

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Main Authors: Beste Turanli, Kubra Karagoz, Gholamreza Bidkhori, Raghu Sinha, Michael L. Gatza, Mathias Uhlen, Adil Mardinoglu, Kazim Yalcin Arga
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019-05-01
Serija:Frontiers in Genetics
Teme:
breast cancer
drug repositioning
non-cancer therapeutics
repurposing
basal subtype
personalized metabolic models
Online dostop:https://www.frontiersin.org/article/10.3389/fgene.2019.00420/full
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