Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway

BACKGROUND: The latent HIV-1 reservoir in treated patients primarily consists of resting memory CD4(+) T cells. Stimulating the T-cell receptor (TCR), which facilitates transition of resting into effector T cells, is the most effective strategy to purge these latently infected cells. Here we supply...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EBioMedicine
Päätekijät: van Montfort, Thijs, van der Sluis, Renée, Darcis, Gilles, Beaty, Doyle, Groen, Kevin, Pasternak, Alexander O., Pollakis, Georgios, Vink, Monique, Westerhout, Ellen M., Hamdi, Mohamed, Bakker, Margreet, van der Putten, Boas, Jurriaans, Suzanne, Prins, Jan H., Jeeninga, Rienk, Thomas, Adri A.M., Speijer, Dave, Berkhout, Ben
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2019
Aiheet:
Research paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491380/
https://ncbi.nlm.nih.gov/pubmed/30824386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.014
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