Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway

BACKGROUND: The latent HIV-1 reservoir in treated patients primarily consists of resting memory CD4(+) T cells. Stimulating the T-cell receptor (TCR), which facilitates transition of resting into effector T cells, is the most effective strategy to purge these latently infected cells. Here we supply...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: van Montfort, Thijs, van der Sluis, Renée, Darcis, Gilles, Beaty, Doyle, Groen, Kevin, Pasternak, Alexander O., Pollakis, Georgios, Vink, Monique, Westerhout, Ellen M., Hamdi, Mohamed, Bakker, Margreet, van der Putten, Boas, Jurriaans, Suzanne, Prins, Jan H., Jeeninga, Rienk, Thomas, Adri A.M., Speijer, Dave, Berkhout, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491380/
https://ncbi.nlm.nih.gov/pubmed/30824386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.014
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