Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway

BACKGROUND: The latent HIV-1 reservoir in treated patients primarily consists of resting memory CD4(+) T cells. Stimulating the T-cell receptor (TCR), which facilitates transition of resting into effector T cells, is the most effective strategy to purge these latently infected cells. Here we supply...

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Publicado en:EBioMedicine
Autores principales: van Montfort, Thijs, van der Sluis, Renée, Darcis, Gilles, Beaty, Doyle, Groen, Kevin, Pasternak, Alexander O., Pollakis, Georgios, Vink, Monique, Westerhout, Ellen M., Hamdi, Mohamed, Bakker, Margreet, van der Putten, Boas, Jurriaans, Suzanne, Prins, Jan H., Jeeninga, Rienk, Thomas, Adri A.M., Speijer, Dave, Berkhout, Ben
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491380/
https://ncbi.nlm.nih.gov/pubmed/30824386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.014
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