Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway

BACKGROUND: The latent HIV-1 reservoir in treated patients primarily consists of resting memory CD4(+) T cells. Stimulating the T-cell receptor (TCR), which facilitates transition of resting into effector T cells, is the most effective strategy to purge these latently infected cells. Here we supply...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: van Montfort, Thijs, van der Sluis, Renée, Darcis, Gilles, Beaty, Doyle, Groen, Kevin, Pasternak, Alexander O., Pollakis, Georgios, Vink, Monique, Westerhout, Ellen M., Hamdi, Mohamed, Bakker, Margreet, van der Putten, Boas, Jurriaans, Suzanne, Prins, Jan H., Jeeninga, Rienk, Thomas, Adri A.M., Speijer, Dave, Berkhout, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491380/
https://ncbi.nlm.nih.gov/pubmed/30824386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.014
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