Lower sarcoplasmic reticulum Ca(2+) threshold for triggering afterdepolarizations in diabetic rat hearts

BACKGROUND: Type-2 diabetes (T2D) increases the arrhythmias risk through incompletely elucidated mechanisms. Ventricular arrhythmias could be initiated by delayed afterdepolarizations (DADs) resulting from elevated spontaneous sarcoplasmic reticulum (SR) Ca(2+) release (SR Ca(2+) leak). OBJECTIVE: T...

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Vydáno v:Heart Rhythm
Hlavní autoři: Popescu, Iuliana, Yin, Guo, Velmurugan, Sathya, Erickson, Jeffrey R., Despa, Florin, Despa, Sanda
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491240/
https://ncbi.nlm.nih.gov/pubmed/30414461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2018.11.001
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