Divalproex sodium modulates nuclear localization of ataxin‐3 and prevents cellular toxicity caused by expanded ataxin‐3

BACKGROUND & AIMS: Spinocerebellar ataxia type 3 (SCA3), also known as Machado‐Joseph disease (MJD), is an autosomal dominantly inherited neurodegenerative disorder and the most common form of SCA worldwide. It is caused by the expansion of a polyglutamine (polyQ) tract in the ataxin‐3 protein....

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Publicado en:CNS Neurosci Ther
Autores principales: Wang, Zi‐Jian, Hanet, Aoife, Weishäupl, Daniel, Martins, Inês M., Sowa, Anna S., Riess, Olaf, Schmidt, Thorsten
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489778/
https://ncbi.nlm.nih.gov/pubmed/29318784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12795
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