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Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway

BACKGROUND: Pancreatic cancer is a major cause of mortality worldwide. Inefficient drugs, their adverse effects, and the development of drug resistance make it difficult to curb the growing incidence of pancreatic cancer. Against this backdrop, the development new drug regimens with no or negligible...

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Bibliografiske detaljer
Udgivet i:Med Sci Monit
Main Authors: Fang, Kaifeng, Wang, Li, Chen, LuJia, Liu, Tao, Fang, Zhi
Format: Artigo
Sprog:Inglês
Udgivet: International Scientific Literature, Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489536/
https://ncbi.nlm.nih.gov/pubmed/31005960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.914244
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