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Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway

BACKGROUND: Pancreatic cancer is a major cause of mortality worldwide. Inefficient drugs, their adverse effects, and the development of drug resistance make it difficult to curb the growing incidence of pancreatic cancer. Against this backdrop, the development new drug regimens with no or negligible...

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Publicado en:Med Sci Monit
Main Authors: Fang, Kaifeng, Wang, Li, Chen, LuJia, Liu, Tao, Fang, Zhi
Formato: Artigo
Idioma:Inglês
Publicado: International Scientific Literature, Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489536/
https://ncbi.nlm.nih.gov/pubmed/31005960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.914244
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