The transcription factor c-Myb regulates CD8(+) T cell stemness and antitumor immunity

Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here we found that the transcription factor c-Myb was essential for generating and maintaining stem cells within the CD8(+) T cell memory compartment. Following viral infection, CD8(+) T cell...

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Publicado no:Nat Immunol
Main Authors: Gautam, Sanjivan, Fioravanti, Jessica, Zhu, Wei, Le Gall, John B., Brohawn, Philip, Lacey, Neal E., Hu, Jinhui, Hocker, James D., Hawk, Nga Voong, Kapoor, Veena, Telford, William G., Gurusamy, Devikala, Yu, Zhiya, Bhandoola, Avinash, Xue, Hai-Hui, Roychoudhuri, Rahul, Higgs, Brandon W., Restifo, Nicholas P., Bender, Timothy P., Ji, Yun, Gattinoni, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489499/
https://ncbi.nlm.nih.gov/pubmed/30778251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0311-z
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