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CRISPR directed evolution of the spliceosome for resistance to splicing inhibitors
Increasing genetic diversity via directed evolution holds great promise to accelerate trait development and crop improvement. We developed a CRISPR/Cas-based directed evolution platform in plants to evolve the rice (Oryza sativa) SF3B1 spliceosomal protein for resistance to splicing inhibitors. SF3B...
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| 出版年: | Genome Biol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6489355/ https://ncbi.nlm.nih.gov/pubmed/31036069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1680-9 |
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