Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by its Dimanganese Cofactor

A ribonucleotide reductase (RNR) from Flavobacterium johnsoniae (Fj) differs fundamentally from known (subclass a-c) class I RNRs, warranting its assignment to a new subclass, Id. Its β subunit shares with Ib counterparts the requirements for manganese(II) and superoxide (O(2)(–)) for activation, bu...

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Publicado no:Biochemistry
Main Authors: Rose, Hannah R., Ghosh, Manas K., Maggiolo, Ailiena O., Pollock, Christopher J., Blaesi, Elizabeth J., Hajj, Viviane, Wei, Yifeng, Rajakovich, Lauren J., Chang, Wei-chen, Han, Yilin, Hajj, Mariana, Krebs, Carsten, Silakov, Alexey, Pandelia, Maria-Eirini, Bollinger, J. Martin, Boal, Amie K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488936/
https://ncbi.nlm.nih.gov/pubmed/29609464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00247
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