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MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric Aβ(25‐35)‐induced anxiety and cognitive deficits in a mouse model

AIMS: Recently, histone deacetylase (HDAC) inhibitors are considered a possible therapeutic strategy in Alzheimer's disease (AD). However, HDACi treatments exhibit diverse functions with unfavorable effects in AD. Thus, the development of selective HDACi without side effects is urgently needed....

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Pubblicato in:CNS Neurosci Ther
Autori principali: Huang, Hei‐Jen, Huang, Hsin‐Yu, Hsieh‐Li, Hsiu Mei
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488906/
https://ncbi.nlm.nih.gov/pubmed/29978554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13029
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