Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure

Cardiomyocyte-specific increases in phosphorylated Hsp20 (S16D-Hsp20) to levels similar to those observed in human failing hearts are associated with early fibrotic remodeling and depressed left ventricular function, symptoms which progress to heart failure and early death. The underlying mechanisms...

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Dades bibliogràfiques
Publicat a:JACC Basic Transl Sci
Autors principals: Gardner, George T., Travers, Joshua G., Qian, Jiang, Liu, Guan-Sheng, Haghighi, Kobra, Robbins, Nathan, Jiang, Min, Li, Yutian, Fan, Guo-Chang, Rubinstein, Jack, Blaxall, Burns C., Kranias, Evangelia G.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
PRECLINICAL RESEARCH
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488766/
https://ncbi.nlm.nih.gov/pubmed/31061921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.11.007
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