Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac...

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Xehetasun bibliografikoak
Argitaratua izan da:JACC Basic Transl Sci
Egile Nagusiak: Takahashi, Tetsuya, Shishido, Tetsuro, Kinoshita, Daisuke, Watanabe, Ken, Toshima, Taku, Sugai, Takayuki, Narumi, Taro, Otaki, Yoichiro, Tamura, Harutoshi, Nishiyama, Satoshi, Arimoto, Takanori, Takahashi, Hiroki, Miyamoto, Takuya, Watanabe, Tetsu, Woo, Chang-Hoon, Abe, Jun-ichi, Takeishi, Yasuchika, Kubota, Isao, Watanabe, Masafumi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2019
Gaiak:
PRECLINICAL RESEARCH
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488753/
https://ncbi.nlm.nih.gov/pubmed/31061925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.11.011
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