Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac...

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Vydáno v:JACC Basic Transl Sci
Hlavní autoři: Takahashi, Tetsuya, Shishido, Tetsuro, Kinoshita, Daisuke, Watanabe, Ken, Toshima, Taku, Sugai, Takayuki, Narumi, Taro, Otaki, Yoichiro, Tamura, Harutoshi, Nishiyama, Satoshi, Arimoto, Takanori, Takahashi, Hiroki, Miyamoto, Takuya, Watanabe, Tetsu, Woo, Chang-Hoon, Abe, Jun-ichi, Takeishi, Yasuchika, Kubota, Isao, Watanabe, Masafumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
PRECLINICAL RESEARCH
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488753/
https://ncbi.nlm.nih.gov/pubmed/31061925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.11.011
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