Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

Caveolin-3 is the major structural protein of caveolae in muscle. Mutations in the CAV3 gene cause different types of myopathies with altered membrane integrity and repair, expression of muscle proteins, and regulation of signaling pathways. We show here that myotubes from patients bearing the CAV3...

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Publicat a:Nat Commun
Autors principals: Dewulf, Melissa, Köster, Darius Vasco, Sinha, Bidisha, Viaris de Lesegno, Christine, Chambon, Valérie, Bigot, Anne, Bensalah, Mona, Negroni, Elisa, Tardif, Nicolas, Podkalicka, Joanna, Johannes, Ludger, Nassoy, Pierre, Butler-Browne, Gillian, Lamaze, Christophe, Blouin, Cedric M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488599/
https://ncbi.nlm.nih.gov/pubmed/31036801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09405-5
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