EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer tension variations at the plasma membrane. Here we show that under mechanical stress, the EHD2 ATPase is rapidly released from caveolae, SUMOylated, and translocated to the nucleus, where it regulates the transcrip...

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Опубликовано в: :J Cell Biol
Главные авторы: Torrino, Stéphanie, Shen, Wei-Wei, Blouin, Cédric M., Mani, Satish Kailasam, Viaris de Lesegno, Christine, Bost, Pierre, Grassart, Alexandre, Köster, Darius, Valades-Cruz, Cesar Augusto, Chambon, Valérie, Johannes, Ludger, Pierobon, Paolo, Soumelis, Vassili, Coirault, Catherine, Vassilopoulos, Stéphane, Lamaze, Christophe
Формат: Artigo
Язык:Inglês
Опубликовано: Rockefeller University Press 2018
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279385/
https://ncbi.nlm.nih.gov/pubmed/30348749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201801122
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