Coumarin derivatives as acetyl- and butyrylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study

Alzheimer's disease is an irreversible and progressive brain disease that can cause problems with memory and thinking skills. It is characterized by loss of cognitive ability and severe behavioral abnormalities, and could lead to death. Cholinesterases (ChEs) play a crucial role in the control...

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Veröffentlicht in:Heliyon
Hauptverfasser: Abu-Aisheh, Marwa N., Al-Aboudi, Amal, Mustafa, Mohammad S., El-Abadelah, Mustafa M., Ali, Saman Yousuf, Ul-Haq, Zaheer, Mubarak, Mohammad S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488543/
https://ncbi.nlm.nih.gov/pubmed/31183424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2019.e01552
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