Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine

Pathogenesis of HIV-associated neurocognitive disorders (HAND) is mediated through the infiltration of perivascular macrophages into the brain with the secretion of viral, neurotoxic and inflammatory proteins. One of these proteins is cathepsin B (CATB), a lysosomal cysteine protease that induces ne...

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書目詳細資料
發表在:J Neuroimmune Pharmacol
Main Authors: López, Omar Vélez, Gorantla, Santhi, Segarra, Annabell C., Andino Norat, María C., Álvarez, Manuel, Skolasky, Richard L., Meléndez, Loyda M.
格式: Artigo
語言:Inglês
出版: Springer US 2018
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488453/
https://ncbi.nlm.nih.gov/pubmed/30306495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-018-9807-4
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