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Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling
T cells are thought to discriminate self from foreign peptides by converting small differences in ligand binding half-life into large changes in cell signaling. Such a kinetic proofreading model has been difficult to test directly, as existing methods of altering ligand binding half-life also change...
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| Pubblicato in: | eLife |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6488292/ https://ncbi.nlm.nih.gov/pubmed/30947808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42498 |
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