Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B (CMT1B) neuropathy, one of the most diffused...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Volpi, Vera G., Ferri, Cinzia, Fregno, Ilaria, Del Carro, Ubaldo, Bianchi, Francesca, Scapin, Cristina, Pettinato, Emanuela, Solda, Tatiana, Feltri, M. Laura, Molinari, Maurizio, Wrabetz, Lawrence, D’Antonio, Maurizio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488099/
https://ncbi.nlm.nih.gov/pubmed/30995221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008069
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