Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification

Biosynthesis of the nucleotide sugar precursor dTDP‐L‐rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS), Streptococcus mutans and Mycobacterium tuberculosis. Streptococcal pathogens require dTDP‐L‐rha...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: van der Beek, Samantha L., Zorzoli, Azul, Çanak, Ebru, Chapman, Robert N., Lucas, Kieron, Meyer, Benjamin H., Evangelopoulos, Dimitrios, de Carvalho, Luiz Pedro S., Boons, Geert‐Jan, Dorfmueller, Helge C., van Sorge, Nina M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487966/
https://ncbi.nlm.nih.gov/pubmed/30600561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14197
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